The Houston Astros head into PNC Park on June 4, 2025, looking to extend their winning streak against the struggling Pittsburgh Pirates. Houston, currently holding a 33-27 record, recently triumphed over the Pirates with a 3-0 victory in Game 1 of their series. Their momentum reflects a strong stretch, having won 7 of their last 9 games, while the Pirates have faltered, losing 3 of 4.

Tonight's matchup features Ryan Gusto taking the mound for the Astros, who brings a 3-2 record with a 4.62 ERA. Gusto's last outing was shaky, allowing 2 earned runs in just 3.2 innings. Facing him is Pittsburgh's Mike Burrows, still looking for his first win after a rough start to the season, posting an 0-1 record and an alarming 8.64 ERA after allowing 4 earned runs in his last appearance. As the teams clash, MLB betting odds favor the Astros at -140 on the moneyline with a total set at 9.0 runs.

The Pittsburgh Pirates will clash with the Arizona Diamondbacks in Phoenix, both teams looking to improve on their recent performances. Pittsburgh, with a 19-36 record, has struggled this season, while Arizona stands at 27-27. Mike Burrows takes the mound for the Pirates, hoping to bounce back from an ERA of 7.20, while Corbin Burnes, boasting a 2.73 ERA, aims to continue his strong start for Arizona. In the previous matchup, the Diamondbacks shut out the Pirates with a solid 5-0 victory, showcasing their potent offense with 10 hits and two home runs from Ryne Nelson's 6.2 innings of work.

The current odds reflect a favored Diamondbacks team with a moneyline of -256, while the Pirates sit at +207. Betting trends indicate that the Diamondbacks have won four of their last five home games against teams with losing records, reinforcing their status as favorites. Additionally, the Pirates have struggled on the road, failing to cover the run line in their last four games. As both teams look to make the most of this matchup, various betting insights will be analyzed to offer predictions and best bets.

The Pittsburgh Pirates are poised for the 2025 season with a solid group of starting pitchers but are looking to enhance their rotation by potentially signing Jakob Junis. As they prepare for an open competition for the fifth starter position, top pitching prospects like Bubba Chandler will be in the mix.

With the recent trade involving Luis L. Ortiz and Spencer Horwitz, the Pirates have room to strengthen their pitching depth. Junis, who had a strong 2024 season with a 2.69 ERA, could provide both a starting option and bullpen flexibility.